Welcome at jangobio
Restoring
hormonal
balance
regenerative therapies to reverse hormone imbalances associated with aging
JangoBio is a pre-clinical stage biotech located in Madison, WI. The company was formed in 2015 to advance novel regenerative medicines for treatment of reproductive hormone imbalance and associated age-related conditions.
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JangoBio is developing regenerative therapies to reverse hormone imbalances associated with aging and thereby mitigate the risk of developing a wide range of age-related diseases.
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Our strategy is to develop cell-based therapeutics capable of correcting the imbalance of circulating reproductive hormones that occurs as a result of disease, or progressively as we age. A regenerative medicine personalized to the patient.
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As our bodies transition from reproductive maturity to middle-age, a milieu of circulating reproductive hormones begin to fall out of balance. These hormones maintain tissues in the body, and imbalance can lead to disease. Men experience a gradual decline in hormone levels beginning at age 30. Women experience changes leading up to menopause, after which hormone levels diverge dramatically. Hormone imbalance is caused by the loss of gonadal cells and their function ('hypogonadism'). The standard treatment with single hormones, such as testosterone or estrogen, does not address this underlying deficit. Our solution is to restore function to gonadal tissues and the spectrum of circulating hormones.
THE BIG PICTURE:
- Traditional Hormone Replacement Therapy
- Next-Generation Hormone Replacement Therapy
- Relevance To Aging And Age-Related Diseases
As our bodies transition from reproductive maturity to middle-age, a milieu of circulating reproductive hormones begin to fall out of balance. These hormones maintain tissues in the body, and imbalance can lead to disease. Men experience a gradual decline in hormone levels beginning at age 30. Women experience changes leading up to menopause, after which hormone levels diverge dramatically. Hormone imbalance is caused by the loss of gonadal cells and their function ('hypogonadism'). The standard treatment with single hormones, such as testosterone or estrogen, does not address this underlying deficit. Our solution is to restore function to gonadal tissues and the spectrum of circulating hormones.
HORMONES STUDIES:
- Hypothalamic-Pituitary-Gonadal (HPG) Hormones
- Imbalance Of Reproductive Hormones In Women Is Associated With Mortality
- Imbalance Of Reproductive Hormones In Men Is Associated With Mortality
- Gonadal Transplantation In Animal Models Increases Life Expectancy
- Heterochronic Parabiosis In Animal Models Suggests A Role For Blood-Borne Factors In Aging
As our bodies transition from reproductive maturity to middle-age, a milieu of circulating reproductive hormones begin to fall out of balance. These hormones maintain tissues in the body, and imbalance can lead to disease. Men experience a gradual decline in hormone levels beginning at age 30. Women experience changes leading up to menopause, after which hormone levels diverge dramatically. Hormone imbalance is caused by the loss of gonadal cells and their function ('hypogonadism'). The standard treatment with single hormones, such as testosterone or estrogen, does not address this underlying deficit. Our solution is to restore function to gonadal tissues and the spectrum of circulating hormones.
SCIENTIFIC PUBLICATIONS:
- Theoretical Considerations
- Studies in Human
- Studies in Animal Models
- Cell Manufacturing
Age (Dordr). 2013 Feb;35(1):129-38.Yonker JA, Chang V, Roetker NS, Hauser TS, Hauser RM, Atwood CS.
Nature News Feature; 21 January 2015Megan Scudellari
Eur J Endocrinol. 2008 Nov;159(5):507-14.Wang C. Nieschlag E, Swerdloff R, Behre HM, Hellstrom WJ, Gooren LJ, Kaufman JM, Legros JJ, Lunenfeld B, Morales A, Morley JE, Schulman C, Thompson IM, Weidner W, Wu FC.
J Clin Endocrinol Metab. 2006 Jun;91(6):1995-2010.Bhasin S, Cunningham GR, Hayes FJ, Matsumoto AM, Snyder PJ, Swerdloff RS, Montori VM.
Exp Gerontol. 2011 Feb-Mar;46(2-3):100-7.Atwood CS, Bowen RL.
Obstet Gynecol. 2009 May;113(5):1027-37. Parker WH, Broder MS, Chang E, Feskanich D, Farquhar C, Liu Z, Shoupe D, Berek JS, Hankinson S, Manson JE.
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